Aimed at a radial transit lines, through considering the time- dependent characteristics of passenger demand and the circumstance that passengers are stranded on platform, a scheduling model of full-length and shortturn routing mode is established, where the objective functions are minimum passenger waiting time, running kilometer of rolling stocks, and operation time of trains, with the constraints of departure interval, scheduling mode, maximum load factor and its’equilibrium. Furthermore, a dynamic simulation model of passengers’ activities and trains’running process is constructed using the discrete event modeling method. Then, a solution method, combined with simulation method and genetic algorithm, is developed. The results show that the disequilibrium train operation scheme can better satisfy the benefits both for the passengers and the operation enterprise, and effectively reduce the crowding of morning rush- hour crush. Comparing with the equilibrium operation scheme, the optimal scheme can reduce the waiting time of passengers by 16.3%, 1 266.2 hours, while the operation cost of transit enterprise remain unchanged.